EIF4E

Across TCGA cell cohorts, EIF4E RNA expression is significantly associated with the go_rna of many other GO terms, with 3,729 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible EIF4E-associated GO terms across cancer lineages are Attachment of spindle microtubules to kinetochore, DNA double-strand break processing, and Mitotic sister chromatid cohesion. Each is linked with EIF4E in more than 15 cancer types. Because this analysis shows association rather than direction, both EIF4E-to-partner and partner-to-EIF4E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Attachment of spindle microtubules to kinetochore grouped by EIF4E-low versus EIF4E-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4E→partner) and Y-score (partner→EIF4E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Attachment of spindle microtubules to kinetochore →	+0.105	+0.681	.009	.005	3	16
OESOPHAGUS	DNA double-strand break processing →	+0.087	+0.763	.006	.007	3	15
UPPER_AERODIGESTIVE_TRACT	Mitotic sister chromatid cohesion →	+0.103	+1.153	.001	.001	3	14
UPPER_AERODIGESTIVE_TRACT	Positive regulation of chromosome condensation →	+0.172	+0.991	<.001	.003	3	14
OESOPHAGUS	Regulation of chromosome condensation →	+0.139	+0.560	.002	.009	3	14
OVARY	Immunoglobulin heavy chain V-D-J recombination →	+0.112	+0.694	.004	.003	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,729 associations by consensus.

Attachment of spindle microtubules to kinetochore by EIF4E expression — KIDNEY

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