EIF4B

Across TCGA patient cohorts, EIF4B protein abundance is significantly associated with the RNA expression of many other genes, with 19,043 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible EIF4B-associated genes across cancer lineages are COPZ1, TARBP2, and PA2G4. Each is linked with EIF4B in more than 7 cancer types. Because this analysis shows association rather than direction, both EIF4B-to-partner and partner-to-EIF4B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EIF4B versus COPZ1 in UCEC, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4B→partner) and Y-score (partner→EIF4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COPZ1 →	+0.435	+0.155	<.001	.001	3	8
UCEC	TARBP2 →	+0.831	+0.263	.004	<.001	3	7
GBM	PA2G4 →	+0.577	+0.228	.001	<.001	3	7
UCEC	SHMT2 →	+0.823	+0.170	<.001	<.001	3	7
OV	ADAMTSL2 →	-1.129	-0.362	<.001	<.001	3	7
OV	IRAG1 →	-0.991	-0.227	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,043 associations by consensus.

EIF4B vs COPZ1 — UCEC

Explore this scatter interactively →