EIF4B

Across TCGA patient cohorts, EIF4B mutation is significantly associated with the RNA expression of many other genes, with 1,820 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF4B-associated genes across cancer lineages are NOM1, SMG1P7, and LINC01717. Each is linked with EIF4B in more than 2 cancer types. Because this analysis shows association rather than direction, both EIF4B-to-partner and partner-to-EIF4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOM1 grouped by EIF4B-low versus EIF4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4B→partner) and Y-score (partner→EIF4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NOM1 →	+0.417	+3.010	<.001	<.001	3	3
UCEC	SMG1P7 →	+0.457	+2.491	<.001	<.001	3	3
SKCM	LINC01717 →	+0.233	+4.732	<.001	<.001	3	3
UCEC	CEP295 →	+0.380	+2.732	.007	.003	3	3
COAD	RNU1-57P →	+1.090	+3.145	<.001	.009	3	3
COAD	LINC01072 →	+0.095	+3.516	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,820 associations by consensus.

NOM1 by EIF4B expression — UCEC

Explore this box plot interactively →