EIF4B

Across TCGA patient cohorts, EIF4B mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF4B-associated genes across cancer lineages are FOXO3a_pS318_S321, 14-3-3_beta, and EGFR_pY1068. Each is linked with EIF4B in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF4B-to-partner and partner-to-EIF4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by EIF4B-low versus EIF4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4B→partner) and Y-score (partner→EIF4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.094	-1.797	.045	.025	3	2
UCEC	14-3-3_beta →	-0.096	-2.295	.011	.033	3	1
UCEC	EGFR_pY1068 →	-0.272	-2.169	.003	.003	3	1
UCEC	eIF4E →	+0.166	+3.700	.035	.001	3	1
UCEC	ERK2 →	+0.212	+2.459	.003	.018	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.377	+2.594	.048	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

FOXO3a_pS318_S321 by EIF4B expression — UCEC

Explore this box plot interactively →