EIF4A3

Across TCGA patient cohorts, EIF4A3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF4A3-associated genes across cancer lineages are p27_pT198, Smad3, and EGFR_pY1068. Each is linked with EIF4A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF4A3-to-partner and partner-to-EIF4A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by EIF4A3-low versus EIF4A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4A3→partner) and Y-score (partner→EIF4A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.126	+3.169	.009	.019	3	2
UCEC	Smad3 →	+0.156	+2.321	.022	.034	3	2
UCEC	EGFR_pY1068 →	-0.240	-2.700	.034	.006	3	1
UCEC	eIF4G →	+0.351	+3.169	.012	.019	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.499	+2.000	.029	.032	3	1
UCEC	MEK1 →	+0.383	+3.321	.020	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

p27_pT198 by EIF4A3 expression — UCEC

Explore this box plot interactively →