EIF4A3

Across TCGA cell cohorts, EIF4A3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,694 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible EIF4A3-associated GO terms across cancer lineages are DNA replication checkpoint signaling, Mitotic DNA replication checkpoint signaling, and Mitotic DNA replication. Each is linked with EIF4A3 in more than 17 cancer types. Because this analysis shows association rather than direction, both EIF4A3-to-partner and partner-to-EIF4A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication checkpoint signaling grouped by EIF4A3-low versus EIF4A3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4A3→partner) and Y-score (partner→EIF4A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication checkpoint signaling →	+0.183	+0.562	.002	.006	3	18
UPPER_AERODIGESTIVE_TRACT	Mitotic DNA replication checkpoint signaling →	+0.131	+0.932	.002	<.001	3	17
LUNG_NSCLC_LUSC	Mitotic DNA replication →	+0.186	+0.859	<.001	<.001	3	16
KIDNEY	Positive regulation of cell cycle phase transition →	+0.119	+0.916	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitotic cell cycle phase transition →	+0.110	+1.049	<.001	.001	3	15
UPPER_AERODIGESTIVE_TRACT	Nuclear DNA replication →	+0.117	+0.921	<.001	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,694 associations by consensus.

DNA replication checkpoint signaling by EIF4A3 expression — BONE

Explore this box plot interactively →