EIF4A3

Across TCGA cell cohorts, EIF4A3 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EIF4A3-associated genes across cancer lineages are PPP1R17, PTH, and GSG1L2. Each is linked with EIF4A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF4A3-to-partner and partner-to-EIF4A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP1R17 grouped by EIF4A3-low versus EIF4A3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4A3→partner) and Y-score (partner→EIF4A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPP1R17 →	+0.055	+4.467	.001	.004	3	1
LARGE_INTESTINE	PTH →	+0.063	+4.684	<.001	.002	3	1
LARGE_INTESTINE	GSG1L2 →	+0.020	+5.022	<.001	.002	3	1
BLOOD_Leukemia	NPFFR1 →	+0.015	+4.037	<.001	.004	3	1
BLOOD_Leukemia	KRT6C →	+0.021	+4.037	<.001	.004	3	1
BLOOD_Leukemia	TEX43 →	+0.084	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PPP1R17 by EIF4A3 expression — LARGE_INTESTINE

Explore this box plot interactively →