EIF4A3

Across TCGA cell cohorts, EIF4A3 mutation is significantly associated with the mutation status of many other genes, with 2,326 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EIF4A3-associated genes across cancer lineages are ITGA5, C4orf50, and MYCBPAP. Each is linked with EIF4A3 in more than 2 cancer types. Because this analysis shows association rather than direction, both EIF4A3-to-partner and partner-to-EIF4A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGA5 grouped by EIF4A3-low versus EIF4A3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4A3→partner) and Y-score (partner→EIF4A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ITGA5 →	+3.087	+4.392	.005	.005	1	3
BLOOD_Leukemia	C4orf50 →	+3.285	+3.662	.004	.004	1	3
LARGE_INTESTINE	MYCBPAP →	+2.865	+4.217	.007	.007	1	3
LARGE_INTESTINE	AP5M1 →	+5.087	+4.523	.006	.006	1	2
LARGE_INTESTINE	ELMO2 →	+3.672	+4.799	.002	.002	1	2
BLOOD_Leukemia	KDM4A →	+4.870	+4.560	<.001	<.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,326 associations by consensus.

ITGA5 by EIF4A3 expression — LARGE_INTESTINE

Explore this box plot interactively →