EIF4A2

Across TCGA pan-cancer cohorts, EIF4A2 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated EIF4A2 data layer compared with 24 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher EIF4A2 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated EIF4A2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UCEC, DLBC, and ESCA are the cancer types where EIF4A2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.973	0.826	.010	18	view →
DLBC	OS	Median	All	0.053	0.936	<.001	12	view →
ESCA	OS	Median	All	0.295	0.704	.013	6	view →
LUAD	OS	Median	All	0.301	0.698	.045	3	view →
BLCA	OS	Median	II,III,IV	0.918	0.699	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

EIF4A2–UCEC (DFS)

Open the UCEC breakdown →