EIF4A1P11

Across TCGA pan-cancer cohorts, EIF4A1P11 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated EIF4A1P11 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher EIF4A1P11 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated EIF4A1P11 expression acts as an unfavorable survival marker, although some lineages such as LUSC and SKCM show a favorable association.

UCEC, LUSC, and MESO are the cancer types where EIF4A1P11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	0.359	0.679	<.001	132	view →
LUSC	OS	Median	All	0.735	0.593	.001	37	view →
MESO	OS	Tertile	IV	0.191	0.695	<.001	36	view →
ACC	OS	Quartile	All	0.235	0.822	<.001	23	view →
OV	OS	Median	IV	0.477	0.744	.009	22	view →
SKCM	OS	Tertile	III,IV	0.870	0.608	.004	17	view →
THCA	OS	Tertile	IV	0.463	0.871	.004	12	view →
KIRP	DFS	Tertile	II,III,IV	0.880	0.413	.011	10	view →
THYM	OS	Quartile	II,III,IV	0.846	1.000	.013	6	view →
BLCA	DFS	Median	II,III,IV	0.599	0.474	.031	4	view →
LUAD	OS	Tertile	III,IV	0.293	0.571	.029	3	view →
CHOL	OS	Quartile	All	0.164	0.709	.010	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

EIF4A1P11–UCEC (DFS)

Open the UCEC breakdown →