EIF4A1

Across TCGA pan-cancer cohorts, EIF4A1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated EIF4A1 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EIF4A1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated EIF4A1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where EIF4A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.930	0.777	.004	35	view →
LUAD	DFS	Tertile	III,IV	0.797	0.175	.001	31	view →
CCRCC	OS	Median	All	0.744	0.915	.005	28	view →
COAD	DFS	Median	II,III,IV	0.910	1.000	.011	12	view →
PDAC	DFS	Median	III,IV	0.200	0.517	.023	6	view →
GBM	OS	Quartile	All	0.445	0.673	.039	3	view →
LSCC	OS	Tertile	II,III,IV	0.851	0.581	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

EIF4A1–HNSC (OS)

Open the HNSC breakdown →