EIF3M

Across TCGA patient cohorts, EIF3M mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF3M-associated genes across cancer lineages are ATM, 14-3-3_beta, and EGFR_pY1068. Each is linked with EIF3M in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF3M-to-partner and partner-to-EIF3M results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by EIF3M-low versus EIF3M-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF3M→partner) and Y-score (partner→EIF3M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.594	-3.321	.003	.010	3	2
UCEC	14-3-3_beta →	-0.139	-3.295	.002	.009	3	1
UCEC	EGFR_pY1068 →	-0.265	-2.700	.019	.006	3	1
UCEC	INPP4B →	-0.372	-2.999	.010	.035	3	1
UCEC	ACVRL1 →	-0.188	-2.000	.002	.032	3	1
UCEC	JNK_pT183_Y185 →	-0.221	-2.459	.003	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ATM by EIF3M expression — UCEC

Explore this box plot interactively →