EIF3L

Across TCGA patient cohorts, EIF3L mutation is significantly associated with the RNA expression of many other genes, with 1,732 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF3L-associated genes across cancer lineages are DSCR4-IT1, GOLGA6C, and RNVU1-25. Each is linked with EIF3L in more than 2 cancer types. Because this analysis shows association rather than direction, both EIF3L-to-partner and partner-to-EIF3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DSCR4-IT1 grouped by EIF3L-low versus EIF3L-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF3L→partner) and Y-score (partner→EIF3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DSCR4-IT1 →	+0.446	+2.111	<.001	.003	3	3
BRCA	GOLGA6C →	+0.027	+5.096	<.001	.008	3	2
BLCA	RNVU1-25 →	+0.677	+2.641	<.001	.005	3	2
COAD	RNU6-539P →	+0.656	+4.289	.004	.003	3	2
SKCM	MYL12BP1 →	+0.367	+2.292	.001	.005	3	2
LGG	RNA5SP509 →	+0.339	+7.977	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,732 associations by consensus.

DSCR4-IT1 by EIF3L expression — SKCM

Explore this box plot interactively →