EIF3L

Across TCGA patient cohorts, EIF3L mutation is significantly associated with the immune_cell of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF3L-associated genes across cancer lineages are Chondrocytes, MPP, and Erythrocytes. Each is linked with EIF3L in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF3L-to-partner and partner-to-EIF3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chondrocytes grouped by EIF3L-low versus EIF3L-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF3L→partner) and Y-score (partner→EIF3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Chondrocytes →	+0.014	+3.109	<.001	.043	3	2
LUAD	MPP →	+0.035	+4.410	<.001	.010	3	2
UCEC	Erythrocytes →	+0.035	+2.321	.005	.036	3	2
UCEC	Th2 cells →	+0.193	+2.321	.033	.036	3	2
SKCM	Smooth muscle →	+0.103	+1.706	.026	.027	3	1
UCEC	Skeletal muscle →	+0.045	+2.332	.040	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Chondrocytes by EIF3L expression — LUSC

Explore this box plot interactively →