EIF3K

Across TCGA pan-cancer cohorts, EIF3K mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated EIF3K data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher EIF3K mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated EIF3K expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where EIF3K mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	II,III,IV	0.416	0.862	.026	26	view →
PDAC	OS	Median	IV	0.491	0.836	.024	15	view →
LUAD	DFS	Quartile	II,III,IV	0.229	1.000	.004	8	view →
LSCC	DFS	Quartile	All	0.852	0.388	.019	3	view →
GBM	DFS	Tertile	All	0.633	0.775	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

EIF3K–CCRCC (OS)

Open the CCRCC breakdown →