EIF3K

Across TCGA patient cohorts, EIF3K mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF3K-associated genes across cancer lineages are A-Raf_pS299, FoxM1, and PDCD4. Each is linked with EIF3K in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF3K-to-partner and partner-to-EIF3K results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by EIF3K-low versus EIF3K-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF3K→partner) and Y-score (partner→EIF3K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.158	-3.000	.004	.036	3	1
UCEC	FoxM1 →	+0.266	+2.584	.027	.011	3	1
UCEC	PDCD4 →	-0.702	-3.700	.001	.001	3	1
UCEC	Rab25 →	-0.494	-2.584	.001	.011	3	1
UCEC	STAT3_pY705 →	-0.409	-3.311	<.001	.010	3	1
UCEC	CD49b →	-0.323	-3.150	.014	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

A-Raf_pS299 by EIF3K expression — UCEC

Explore this box plot interactively →