EIF3G

Across TCGA pan-cancer cohorts, EIF3G mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated EIF3G data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EIF3G mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated EIF3G expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

HNSC, COAD, and PDAC are the cancer types where EIF3G mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	1.000	0.107	.010	41	view →
COAD	DFS	Tertile	All	1.000	0.866	.034	12	view →
PDAC	DFS	Tertile	All	0.891	0.732	.028	8	view →
LUAD	DFS	Tertile	All	0.993	0.840	.037	3	view →
LSCC	DFS	Median	All	0.888	0.522	.037	2	view →
GBM	DFS	Median	All	0.663	0.834	.023	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

EIF3G–HNSC (OS)

Open the HNSC breakdown →