EIF3F

Across TCGA pan-cancer cohorts, EIF3F mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated EIF3F data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher EIF3F mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated EIF3F expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

UCEC, HNSC, and PDAC are the cancer types where EIF3F mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	0.258	0.924	.001	40	view →
HNSC	DFS	Median	III,IV	0.934	0.652	<.001	34	view →
PDAC	DFS	Quartile	II,III,IV	0.775	0.471	.007	12	view →
LSCC	DFS	Quartile	All	0.890	0.626	.014	8	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
LUAD	DFS	Tertile	All	0.995	0.818	.027	4	view →
GBM	DFS	Tertile	All	0.694	0.844	.032	4	view →
CCRCC	OS	Median	All	0.748	0.922	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

EIF3F–UCEC (DFS)

Open the UCEC breakdown →