EIF3E

Across TCGA pan-cancer cohorts, EIF3E Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated EIF3E data layer compared with 27 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher EIF3E Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated EIF3E expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRC, UCEC, and ESCA are the cancer types where EIF3E Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.122	0.811	<.001	36	view →
UCEC	DFS	Median	All	1.000	0.610	.002	24	view →
ESCA	OS	Median	II,III,IV	0.103	0.868	<.001	18	view →
BLCA	DFS	Median	IV	0.177	0.481	.025	6	view →
SKCM	OS	Median	IV	0.179	0.755	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

EIF3E–KIRC (OS)

Open the KIRC breakdown →