EIF3E

Across TCGA patient cohorts, EIF3E mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF3E-associated genes across cancer lineages are TFRC, ATM, and C-Raf. Each is linked with EIF3E in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF3E-to-partner and partner-to-EIF3E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by EIF3E-low versus EIF3E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF3E→partner) and Y-score (partner→EIF3E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.470	+3.321	.013	.009	3	2
UCEC	ATM →	-0.558	-2.321	<.001	.001	3	2
UCEC	C-Raf →	+0.200	+3.000	<.001	<.001	3	2
UCEC	FoxM1 →	+0.238	+2.321	.010	.001	3	1
UCEC	HER3_pY1289 →	+0.066	+2.019	.034	.017	3	1
UCEC	INPP4B →	-0.333	-2.700	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

TFRC by EIF3E expression — UCEC

Explore this box plot interactively →