EIF3D

Across TCGA pan-cancer cohorts, EIF3D mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated EIF3D data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EIF3D mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated EIF3D expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where EIF3D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.849	0.562	.002	68	view →
CCRCC	OS	Median	All	0.741	0.938	.001	25	view →
LUAD	DFS	Median	All	0.981	0.824	.013	19	view →
PDAC	OS	Median	III,IV	0.610	0.882	.014	18	view →
UCEC	DFS	Tertile	II,III,IV	0.545	0.916	.044	12	view →
GBM	DFS	Median	All	0.642	0.782	.007	2	view →
LSCC	OS	Median	All	0.767	1.000	.015	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

EIF3D–HNSC (DFS)

Open the HNSC breakdown →