EIF3D

Across TCGA patient cohorts, EIF3D mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF3D-associated genes across cancer lineages are MEK1, BRD4, and 4E-BP1. Each is linked with EIF3D in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF3D-to-partner and partner-to-EIF3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by EIF3D-low versus EIF3D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF3D→partner) and Y-score (partner→EIF3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.645	+3.169	.001	.020	2	2
UCEC	BRD4 →	+0.300	+2.818	.041	.035	3	1
UCEC	4E-BP1 →	+0.356	+3.169	.016	.020	3	1
UCEC	MSH2 →	-0.352	-3.160	.005	.019	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MEK1 by EIF3D expression — UCEC

Explore this box plot interactively →