EIF3D

Across TCGA cell cohorts, EIF3D mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EIF3D-associated genes across cancer lineages are IQCF5, RBMY1A1, and ARMS2. Each is linked with EIF3D in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF3D-to-partner and partner-to-EIF3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by EIF3D-low versus EIF3D-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF3D→partner) and Y-score (partner→EIF3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IQCF5 →	+0.121	+5.201	<.001	.006	3	2
OVARY	RBMY1A1 →	+0.086	+4.222	<.001	.006	3	1
OVARY	ARMS2 →	+0.088	+4.115	<.001	.002	3	1
LARGE_INTESTINE	IAPP →	+0.414	+3.906	<.001	.005	3	1
LARGE_INTESTINE	NXF5 →	+0.031	+3.882	<.001	.001	3	1
LARGE_INTESTINE	RFPL3 →	+0.042	+3.510	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

IQCF5 by EIF3D expression — BLOOD_Leukemia

Explore this box plot interactively →