Across TCGA pan-cancer cohorts, EIF3CL RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated EIF3CL data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher EIF3CL RNA is associated with worse overall survival. In most high-consensus cancer types, elevated EIF3CL expression acts as an unfavorable survival marker, although some lineages such as LUSC and SCLC show a favorable association.

LIHC, LUSC, and UCS are the cancer types where EIF3CL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.429	0.658	<.001	52	view →
LUSC	OS	Median	II,III,IV	0.720	0.501	<.001	42	view →
UCS	DFS	Median	All	0.373	0.663	.002	36	view →
SCLC	OS	Tertile	All	0.604	0.198	<.001	33	view →
LUAD	OS	Quartile	All	0.730	0.852	.005	33	view →
BLCA	DFS	Quartile	II,III,IV	0.561	0.692	.005	32	view →
KIRC	DFS	Tertile	All	0.786	0.505	.002	28	view →
UCEC	DFS	Tertile	All	0.764	0.871	.004	14	view →
STAD	DFS	Median	All	0.463	0.602	.012	12	view →
UVM	DFS	Median	II,III,IV	0.740	0.409	.007	11	view →
READ	OS	Tertile	All	0.919	0.655	.017	9	view →
THCA	DFS	Tertile	IV	0.407	0.824	.011	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

Exploration

Same gene, other analysis: EIF3CL tumor-vs-normal RNA expression · all EIF3CL data types