Across TCGA cell cohorts, EIF3C mutation is significantly associated with the RNA expression of many other genes, with 240 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EIF3C-associated genes across cancer lineages are OR2B11, HTN1, and SPINK9. Each is linked with EIF3C in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF3C-to-partner and partner-to-EIF3C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF3C→partner) and Y-score (partner→EIF3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR2B11 →	+0.024	+3.869	<.001	.002	3	2
BREAST	HTN1 →	+0.068	+2.990	<.001	.007	3	2
CNS	SPINK9 →	+0.052	+4.321	<.001	<.001	3	2
STOMACH	SEBOX →	+0.054	+4.044	<.001	.003	3	2
LARGE_INTESTINE	ST13 →	+0.428	+3.459	.006	.001	3	2
LARGE_INTESTINE	SRF →	+0.547	+2.244	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 240 associations by consensus.

Exploration

EIF3C survival (RNA) · tumor vs normal (RNA) · all EIF3C data types