EIF3B

Across TCGA pan-cancer cohorts, EIF3B mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated EIF3B data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher EIF3B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated EIF3B expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

CCRCC, HNSC, and UCEC are the cancer types where EIF3B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	0.549	0.918	<.001	20	view →
HNSC	OS	Median	III,IV	0.926	0.778	.021	11	view →
UCEC	DFS	Median	All	0.934	1.000	.018	10	view →
PDAC	DFS	Median	III,IV	0.537	0.813	.006	10	view →
COAD	DFS	Median	All	1.000	0.922	.018	6	view →
GBM	DFS	Quartile	All	0.693	0.898	.012	5	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.386	.024	5	view →
LUAD	DFS	Quartile	All	0.509	1.000	.019	4	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

EIF3B–CCRCC (DFS)

Open the CCRCC breakdown →