EIF3B

Across TCGA patient cohorts, EIF3B mutation is significantly associated with the RNA expression of many other genes, with 3,206 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF3B-associated genes across cancer lineages are RNU6-1156P, H3P9, and LINC02136. Each is linked with EIF3B in more than 2 cancer types. Because this analysis shows association rather than direction, both EIF3B-to-partner and partner-to-EIF3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1156P grouped by EIF3B-low versus EIF3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF3B→partner) and Y-score (partner→EIF3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1156P →	+0.270	+1.971	.007	.009	3	3
LUAD	H3P9 →	+0.380	+4.598	.001	.004	3	2
LUAD	LINC02136 →	+0.442	+4.426	<.001	.006	3	2
UCEC	VTI1A →	+0.388	+2.523	.002	.001	3	2
UCEC	ANKRD9 →	+0.547	+3.660	<.001	.001	3	2
SKCM	SUPV3L1 →	+0.436	+3.436	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,206 associations by consensus.

RNU6-1156P by EIF3B expression — UCEC

Explore this box plot interactively →