EIF3B

Across TCGA cell cohorts, EIF3B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,280 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible EIF3B-associated GO terms across cancer lineages are Transcription by RNA polymerase I, Transcription initiation at RNA polymerase I promoter, and Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with EIF3B in more than 17 cancer types. Because this analysis shows association rather than direction, both EIF3B-to-partner and partner-to-EIF3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription by RNA polymerase I grouped by EIF3B-low versus EIF3B-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF3B→partner) and Y-score (partner→EIF3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Transcription by RNA polymerase I →	+0.121	+0.904	<.001	<.001	3	17
SOFT_TISSUE	Transcription initiation at RNA polymerase I promoter →	+0.139	+0.967	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.150	+0.701	.005	.003	2	18
LUNG_NSCLC_LUSC	rRNA 5'-end processing →	+0.150	+0.701	.005	.003	2	18
SOFT_TISSUE	DNA-templated transcription termination →	+0.094	+0.776	.003	.003	3	17
OESOPHAGUS	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.167	+1.253	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,280 associations by consensus.

Transcription by RNA polymerase I by EIF3B expression — PANCREAS

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