EIF3B

Across TCGA cell cohorts, EIF3B mutation is significantly associated with the RNA expression of many other genes, with 1,051 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EIF3B-associated genes across cancer lineages are DCD, C10orf53, and EDDM3A. Each is linked with EIF3B in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF3B-to-partner and partner-to-EIF3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCD grouped by EIF3B-low versus EIF3B-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF3B→partner) and Y-score (partner→EIF3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DCD →	+0.040	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	C10orf53 →	+0.028	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	EDDM3A →	+0.640	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OR2T4 →	+0.022	+5.209	<.001	.005	3	1
BREAST	KRT25 →	+0.063	+4.421	<.001	.004	3	1
BREAST	USP17L8 →	+0.005	+4.781	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,051 associations by consensus.

DCD by EIF3B expression — BLOOD_Lymphoma

Explore this box plot interactively →