EIF3A

Across TCGA cell cohorts, EIF3A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,892 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible EIF3A-associated GO terms across cancer lineages are Viral translational termination-reinitiation, Subtelomeric heterochromatin formation, and Regulation of sister chromatid cohesion. Each is linked with EIF3A in more than 16 cancer types. Because this analysis shows association rather than direction, both EIF3A-to-partner and partner-to-EIF3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Viral translational termination-reinitiation grouped by EIF3A-low versus EIF3A-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF3A→partner) and Y-score (partner→EIF3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Viral translational termination-reinitiation →	+0.098	+0.941	<.001	<.001	3	17
SKIN	Subtelomeric heterochromatin formation →	+0.126	+0.958	<.001	<.001	3	14
SOFT_TISSUE	Regulation of sister chromatid cohesion →	+0.109	+0.790	<.001	<.001	3	14
SKIN	Phosphatidylinositol biosynthetic process →	+0.065	+0.794	<.001	<.001	3	13
OVARY	Nuclear export →	+0.080	+0.895	<.001	<.001	3	13
BONE	Symbiont-mediated disruption of host cell PML body →	+0.093	+0.783	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,892 associations by consensus.

Viral translational termination-reinitiation by EIF3A expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →