EIF3A

Across TCGA cell cohorts, EIF3A mutation is significantly associated with the mutation status of many other genes, with 5,092 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EIF3A-associated genes across cancer lineages are COL4A4, CASZ1, and PLCB2. Each is linked with EIF3A in more than 6 cancer types. Because this analysis shows association rather than direction, both EIF3A-to-partner and partner-to-EIF3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COL4A4 grouped by EIF3A-low versus EIF3A-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF3A→partner) and Y-score (partner→EIF3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	COL4A4 →	+4.000	+4.000	.002	.002	1	7
LUNG_NSCLC_LUAD	CASZ1 →	+3.924	+5.063	.001	.001	1	5
SOFT_TISSUE	PLCB2 →	+4.502	+5.066	.007	.007	1	5
OVARY	SBF1 →	+3.310	+4.688	<.001	<.001	1	5
CNS	TG →	+2.830	+3.775	.002	.002	1	5
OVARY	KIF1A →	+3.217	+3.684	.006	.006	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,092 associations by consensus.

COL4A4 by EIF3A expression — CNS

Explore this box plot interactively →