EIF2S3B

Across TCGA cell cohorts, EIF2S3B RNA expression is significantly associated with the go_rna of many other GO terms, with 2,794 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible EIF2S3B-associated GO terms across cancer lineages are Formation of translation preinitiation complex, Viral translational termination-reinitiation, and SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Each is linked with EIF2S3B in more than 9 cancer types. Because this analysis shows association rather than direction, both EIF2S3B-to-partner and partner-to-EIF2S3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Formation of translation preinitiation complex grouped by EIF2S3B-low versus EIF2S3B-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2S3B→partner) and Y-score (partner→EIF2S3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Formation of translation preinitiation complex →	-0.116	-1.067	<.001	<.001	3	10
LARGE_INTESTINE	Viral translational termination-reinitiation →	+0.091	+1.068	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process →	+0.049	+1.093	<.001	.001	3	10
SOFT_TISSUE	Transcription pausing by RNA polymerase II →	+0.116	+1.263	<.001	<.001	3	9
SOFT_TISSUE	Subtelomeric heterochromatin formation →	+0.138	+1.228	<.001	<.001	3	9
LARGE_INTESTINE	Response to dehydroepiandrosterone →	+0.225	+0.789	.007	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,794 associations by consensus.

Formation of translation preinitiation complex by EIF2S3B expression — BREAST

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