EIF2S2

Across TCGA patient cohorts, EIF2S2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF2S2-associated genes across cancer lineages are A-Raf_pS299, JNK2, and STAT3_pY705. Each is linked with EIF2S2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF2S2-to-partner and partner-to-EIF2S2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by EIF2S2-low versus EIF2S2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2S2→partner) and Y-score (partner→EIF2S2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.099	-1.584	.035	.036	3	1
UCEC	JNK2 →	+0.215	+1.584	.005	.036	3	1
UCEC	STAT3_pY705 →	-0.271	-1.584	.008	.036	3	1
UCEC	VHL →	-0.791	-2.000	.002	.010	3	1
UCEC	beta-Catenin →	+0.497	+1.584	.012	.036	3	1
UCEC	4E-BP1_pT37_T46 →	-0.314	-1.986	.033	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

A-Raf_pS299 by EIF2S2 expression — UCEC

Explore this box plot interactively →