EIF2S1

Across TCGA patient cohorts, EIF2S1 protein abundance is significantly associated with the RNA expression of many other genes, with 13,441 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible EIF2S1-associated genes across cancer lineages are MTHFD1, CDKN3, and DCAF4. Each is linked with EIF2S1 in more than 6 cancer types. Because this analysis shows association rather than direction, both EIF2S1-to-partner and partner-to-EIF2S1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EIF2S1 versus MTHFD1 in UCEC, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2S1→partner) and Y-score (partner→EIF2S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTHFD1 →	+0.605	+0.192	<.001	<.001	3	7
OV	CDKN3 →	+1.076	+0.189	<.001	<.001	3	6
LSCC	DCAF4 →	+0.460	+0.160	<.001	<.001	3	6
UCEC	DLGAP5 →	+1.336	+0.198	<.001	<.001	3	6
COAD	N4BP2L1 →	-0.790	-0.136	<.001	.009	3	6
LUAD	WDHD1 →	+0.736	+0.225	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,441 associations by consensus.

EIF2S1 vs MTHFD1 — UCEC

Explore this scatter interactively →