EIF2S1

Across TCGA patient cohorts, EIF2S1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF2S1-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and Heregulin. Each is linked with EIF2S1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF2S1-to-partner and partner-to-EIF2S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by EIF2S1-low versus EIF2S1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2S1→partner) and Y-score (partner→EIF2S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.361	-2.807	<.001	.003	3	1
UCEC	FoxM1 →	+0.352	+3.906	.001	<.001	3	1
UCEC	Heregulin →	-0.142	-2.115	.008	.019	3	1
UCEC	Ku80 →	+0.295	+2.331	.004	.019	3	1
UCEC	mTOR_pS2448 →	-0.142	-2.308	.029	.033	3	1
UCEC	Notch1 →	+0.156	+3.331	.011	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

EGFR_pY1068 by EIF2S1 expression — UCEC

Explore this box plot interactively →