EIF2S1

Across TCGA cell cohorts, EIF2S1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,666 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EIF2S1-associated GO terms across cancer lineages are DNA recombination, Response to manganese-induced endoplasmic reticulum stress, and rRNA 5'-end processing. Each is linked with EIF2S1 in more than 16 cancer types. Because this analysis shows association rather than direction, both EIF2S1-to-partner and partner-to-EIF2S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA recombination grouped by EIF2S1-low versus EIF2S1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2S1→partner) and Y-score (partner→EIF2S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA recombination →	+0.087	+1.398	<.001	.001	3	17
SOFT_TISSUE	Response to manganese-induced endoplasmic reticulum stress →	+0.088	+1.206	<.001	<.001	3	17
OESOPHAGUS	rRNA 5'-end processing →	+0.144	+0.981	.001	.001	3	16
BONE	Protein localization to condensed chromosome →	+0.153	+0.834	.004	.001	3	16
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication maintenance of fidelity →	+0.119	+1.312	.001	<.001	3	16
OESOPHAGUS	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.144	+0.981	.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,666 associations by consensus.

DNA recombination by EIF2S1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →