EIF2B5

Across TCGA patient cohorts, EIF2B5 mutation is significantly associated with the RNA expression of many other genes, with 3,485 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF2B5-associated genes across cancer lineages are EEF1E1-BLOC1S5, RNU7-26P, and OXA1L. Each is linked with EIF2B5 in more than 2 cancer types. Because this analysis shows association rather than direction, both EIF2B5-to-partner and partner-to-EIF2B5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EEF1E1-BLOC1S5 grouped by EIF2B5-low versus EIF2B5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2B5→partner) and Y-score (partner→EIF2B5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	EEF1E1-BLOC1S5 →	+0.062	+3.766	<.001	.005	3	3
SKCM	RNU7-26P →	+0.504	+3.490	<.001	.008	3	3
UCEC	OXA1L →	+0.399	+2.736	<.001	<.001	3	2
UCEC	ABHD3 →	+0.798	+3.403	<.001	<.001	3	2
UCEC	ENTR1 →	+0.427	+3.716	.001	<.001	3	2
UCEC	MTMR10 →	+0.476	+3.413	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,485 associations by consensus.

EEF1E1-BLOC1S5 by EIF2B5 expression — SKCM

Explore this box plot interactively →