EIF2B5

Across TCGA patient cohorts, EIF2B5 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF2B5-associated genes across cancer lineages are eIF4E, ASNS, and Caspase-7-cleavedD198. Each is linked with EIF2B5 in more than 3 cancer types. Because this analysis shows association rather than direction, both EIF2B5-to-partner and partner-to-EIF2B5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by EIF2B5-low versus EIF2B5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2B5→partner) and Y-score (partner→EIF2B5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.198	+2.087	.014	.005	3	3
COAD	ASNS →	+0.689	+2.815	.001	.036	3	2
COAD	Caspase-7-cleavedD198 →	+1.413	+2.815	.001	.036	1	4
UCEC	FoxM1 →	+0.221	+2.584	.026	.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.343	-2.999	.047	.035	3	2
UCEC	PDCD4 →	-0.563	-3.459	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

eIF4E by EIF2B5 expression — UCEC

Explore this box plot interactively →