EIF2B5

Across TCGA cell cohorts, EIF2B5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,104 significant associations in total. BONE shows the largest number of these associations.

The most reproducible EIF2B5-associated GO terms across cancer lineages are Maintenance of centrosome location, Ribosome localization, and Negative regulation of hemopoiesis. Each is linked with EIF2B5 in more than 18 cancer types. Because this analysis shows association rather than direction, both EIF2B5-to-partner and partner-to-EIF2B5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maintenance of centrosome location grouped by EIF2B5-low versus EIF2B5-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2B5→partner) and Y-score (partner→EIF2B5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Maintenance of centrosome location →	+0.158	+1.120	<.001	<.001	3	19
CNS	Ribosome localization →	+0.099	+0.351	<.001	.001	3	13
LIVER	Negative regulation of hemopoiesis →	-0.122	-0.496	.001	.005	3	13
CNS	Ribosomal subunit export from nucleus →	+0.099	+0.351	<.001	.001	3	13
BONE	Cell cycle checkpoint signaling →	+0.103	+0.725	.003	<.001	3	13
LUNG_NSCLC_LUSC	DNA repair-dependent chromatin remodeling →	+0.130	+1.440	.002	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,104 associations by consensus.

Maintenance of centrosome location by EIF2B5 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →