EIF2B5

Across TCGA cell cohorts, EIF2B5 mutation is significantly associated with the mutation status of many other genes, with 3,581 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EIF2B5-associated genes across cancer lineages are SORBS2, CAMSAP1, and DUOX1. Each is linked with EIF2B5 in more than 3 cancer types. Because this analysis shows association rather than direction, both EIF2B5-to-partner and partner-to-EIF2B5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SORBS2 grouped by EIF2B5-low versus EIF2B5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2B5→partner) and Y-score (partner→EIF2B5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SORBS2 →	+4.157	+5.430	<.001	<.001	1	4
BLOOD_Leukemia	CAMSAP1 →	+3.157	+4.665	.003	.003	1	4
BLOOD_Lymphoma	DUOX1 →	+4.014	+4.969	.008	.008	1	4
BLOOD_Leukemia	GREB1L →	+4.309	+4.560	.007	.007	1	4
BLOOD_Lymphoma	SLC4A10 →	+4.429	+5.247	.005	.005	1	4
BLOOD_Lymphoma	CHPF2 →	+5.014	+5.584	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,581 associations by consensus.

SORBS2 by EIF2B5 expression — BLOOD_Leukemia

Explore this box plot interactively →