EIF2B4

Across TCGA pan-cancer cohorts, EIF2B4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated EIF2B4 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher EIF2B4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated EIF2B4 expression acts as an unfavorable survival marker, although some lineages such as COAD show a favorable association.

COAD, GBM, and HNSC are the cancer types where EIF2B4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.920	.014	24	view →
GBM	DFS	Quartile	All	0.303	0.545	.015	16	view →
HNSC	DFS	Tertile	IV	0.596	0.935	.013	11	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

EIF2B4–COAD (DFS)

Open the COAD breakdown →