EIF2B4

Across TCGA patient cohorts, EIF2B4 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF2B4-associated genes across cancer lineages are ASNS, FOXO3a_pS318_S321, and MEK1. Each is linked with EIF2B4 in more than 2 cancer types. Because this analysis shows association rather than direction, both EIF2B4-to-partner and partner-to-EIF2B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by EIF2B4-low versus EIF2B4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2B4→partner) and Y-score (partner→EIF2B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.621	+3.321	<.001	.010	2	3
UCEC	FOXO3a_pS318_S321 →	-0.121	-3.449	.026	.005	3	1
UCEC	MEK1 →	+0.429	+3.321	.007	.009	3	1
UCEC	MIG-6 →	+0.091	+1.598	.036	.044	3	1
UCEC	mTOR_pS2448 →	-0.142	-3.156	.029	.018	3	1
UCEC	p62 Lck ligand →	+0.383	+2.179	.007	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ASNS by EIF2B4 expression — UCEC

Explore this box plot interactively →