EIF2B4

Across TCGA cell cohorts, EIF2B4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,578 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible EIF2B4-associated GO terms across cancer lineages are Mitochondrial DNA metabolic process, Positive regulation of intracellular steroid hormone receptor signaling pathway, and Positive regulation of intracellular estrogen receptor signaling pathway. Each is linked with EIF2B4 in more than 10 cancer types. Because this analysis shows association rather than direction, both EIF2B4-to-partner and partner-to-EIF2B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial DNA metabolic process grouped by EIF2B4-low versus EIF2B4-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2B4→partner) and Y-score (partner→EIF2B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Mitochondrial DNA metabolic process →	+0.092	+0.699	<.001	<.001	3	11
URINARY_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.155	+0.651	.001	.002	3	11
SOFT_TISSUE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.161	+0.759	<.001	<.001	3	11
BONE	tRNA transcription →	+0.127	+0.740	.005	<.001	3	11
SOFT_TISSUE	Base-excision repair, gap-filling →	+0.082	+0.509	.001	.001	3	11
PANCREAS	'de novo' UMP biosynthetic process →	+0.111	+0.501	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,578 associations by consensus.

Mitochondrial DNA metabolic process by EIF2B4 expression — BREAST

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