EIF2B3

Across TCGA patient cohorts, EIF2B3 mutation is significantly associated with the RNA expression of many other genes, with 1,787 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF2B3-associated genes across cancer lineages are RPS10P21, TUBAP15, and RN7SL147P. Each is linked with EIF2B3 in more than 2 cancer types. Because this analysis shows association rather than direction, both EIF2B3-to-partner and partner-to-EIF2B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS10P21 grouped by EIF2B3-low versus EIF2B3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2B3→partner) and Y-score (partner→EIF2B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RPS10P21 →	+0.422	+4.984	<.001	.009	3	3
SKCM	TUBAP15 →	+0.142	+3.573	.009	.009	3	2
CESC	RN7SL147P →	+0.110	+4.969	<.001	.004	3	2
LUAD	SSX4 →	+0.033	+4.730	.001	.005	3	2
SKCM	TUBB4BP8 →	+0.032	+4.624	<.001	.005	3	2
SKCM	UFL1-AS1 →	+0.183	+3.721	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,787 associations by consensus.

RPS10P21 by EIF2B3 expression — LUSC

Explore this box plot interactively →