EIF2B3

Across TCGA cell cohorts, EIF2B3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,251 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible EIF2B3-associated GO terms across cancer lineages are Negative regulation of chromosome segregation, DNA replication initiation, and Regulation of metaphase/anaphase transition of cell cycle. Each is linked with EIF2B3 in more than 15 cancer types. Because this analysis shows association rather than direction, both EIF2B3-to-partner and partner-to-EIF2B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome segregation grouped by EIF2B3-low versus EIF2B3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2B3→partner) and Y-score (partner→EIF2B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome segregation →	+0.140	+0.849	.001	.001	3	16
BLOOD_Myeloma	DNA replication initiation →	+0.175	+1.064	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Regulation of metaphase/anaphase transition of cell cycle →	+0.120	+1.159	<.001	<.001	3	15
KIDNEY	Regulation of chromosome separation →	+0.191	+0.922	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of chromosome condensation →	+0.197	+1.083	.001	<.001	3	15
PANCREAS	Regulation of mitotic metaphase/anaphase transition →	+0.134	+1.147	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,251 associations by consensus.

Negative regulation of chromosome segregation by EIF2B3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →