EIF2B1

Across TCGA patient cohorts, EIF2B1 mutation is significantly associated with the RNA expression of many other genes, with 797 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF2B1-associated genes across cancer lineages are OR1D4, RNA5SP369, and RNVU1-28. Each is linked with EIF2B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF2B1-to-partner and partner-to-EIF2B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1D4 grouped by EIF2B1-low versus EIF2B1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2B1→partner) and Y-score (partner→EIF2B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	OR1D4 →	+0.068	+5.688	<.001	<.001	3	2
CESC	RNA5SP369 →	+0.254	+4.539	.003	.008	3	2
CESC	RNVU1-28 →	+0.570	+4.705	<.001	.003	3	2
UCEC	EIF1AY →	+0.025	+2.566	<.001	.002	3	2
UCEC	RNA5SP478 →	+0.112	+4.276	<.001	.005	3	2
UCEC	RNU6-1 →	+0.552	+3.764	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 797 associations by consensus.

OR1D4 by EIF2B1 expression — CESC

Explore this box plot interactively →