EIF2B1

Across TCGA patient cohorts, EIF2B1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF2B1-associated genes across cancer lineages are GAPDH, INPP4B, and Src_pY416. Each is linked with EIF2B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF2B1-to-partner and partner-to-EIF2B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by EIF2B1-low versus EIF2B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2B1→partner) and Y-score (partner→EIF2B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.696	+3.169	.018	.020	3	1
UCEC	INPP4B →	-0.359	-2.999	.043	.035	3	1
UCEC	Src_pY416 →	-0.316	-3.156	.016	.020	3	1
UCEC	Bak →	+0.368	+3.169	.007	.020	3	1
UCEC	PDCD4 →	-0.981	-3.160	<.001	.019	2	1
UCEC	ATM →	-0.769	-3.169	.001	.020	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

GAPDH by EIF2B1 expression — UCEC

Explore this box plot interactively →