EIF2AK2

Across TCGA patient cohorts, EIF2AK2 protein abundance is significantly associated with the RNA expression of many other genes, with 9,514 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible EIF2AK2-associated genes across cancer lineages are DDX58, OAS3, and OAS2. Each is linked with EIF2AK2 in more than 9 cancer types. Because this analysis shows association rather than direction, both EIF2AK2-to-partner and partner-to-EIF2AK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EIF2AK2 versus DDX58 in HNSC, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2AK2→partner) and Y-score (partner→EIF2AK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DDX58 →	+1.119	+0.322	<.001	<.001	3	10
LSCC	OAS3 →	+1.311	+0.429	<.001	<.001	3	10
BRCA	OAS2 →	+1.411	+0.372	<.001	<.001	3	10
OV	IFIH1 →	+1.135	+0.437	<.001	<.001	3	10
BRCA	XAF1 →	+1.014	+0.347	<.001	<.001	3	10
OV	RSAD2 →	+1.571	+0.404	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,514 associations by consensus.

EIF2AK2 vs DDX58 — HNSC

Explore this scatter interactively →