EIF2AK2

Across TCGA patient cohorts, EIF2AK2 mutation is significantly associated with the RNA expression of many other genes, with 2,668 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF2AK2-associated genes across cancer lineages are MIR7-3, RNU6-709P, and MIR3148. Each is linked with EIF2AK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both EIF2AK2-to-partner and partner-to-EIF2AK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR7-3 grouped by EIF2AK2-low versus EIF2AK2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2AK2→partner) and Y-score (partner→EIF2AK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MIR7-3 →	+0.806	+4.401	<.001	.006	3	3
STAD	RNU6-709P →	+0.667	+4.646	<.001	.004	3	3
STAD	MIR3148 →	+0.449	+4.798	<.001	.006	3	3
LUAD	RNU6-1328P →	+0.357	+7.930	<.001	.008	3	2
STAD	RNU6-768P →	+0.753	+4.691	<.001	.003	3	2
STAD	MIR1237 →	+0.228	+6.091	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,668 associations by consensus.

MIR7-3 by EIF2AK2 expression — STAD

Explore this box plot interactively →