EIF2AK2

Across TCGA patient cohorts, EIF2AK2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF2AK2-associated genes across cancer lineages are beta-Catenin, 14-3-3_beta, and eEF2. Each is linked with EIF2AK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF2AK2-to-partner and partner-to-EIF2AK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, beta-Catenin grouped by EIF2AK2-low versus EIF2AK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2AK2→partner) and Y-score (partner→EIF2AK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	beta-Catenin →	+0.347	+1.502	.041	.027	3	2
UCEC	14-3-3_beta →	-0.086	-1.973	.010	.029	3	1
UCEC	eEF2 →	+0.277	+1.874	.020	.049	3	1
UCEC	ERK2 →	+0.134	+1.874	.037	.049	3	1
UCEC	FoxM1 →	+0.201	+1.584	.020	.009	3	1
UCEC	GAPDH →	+0.444	+2.459	.013	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

beta-Catenin by EIF2AK2 expression — UCEC

Explore this box plot interactively →